The Research Scientist III, Assay Development & Screening is expected to routinely demonstrate problem solving skills and work independently on complex tasks. They are expected to demonstrate expertise in both the theoretical and practical aspects of the development and validation of screening assays and execution of screening campaigns using workstations or fully integrated screening systems. Principal responsibilities are: development of the reagents and assays for testing of natural product and synthetic samples using biochemical and cell-based assays; assay automation and compound screening; analysis and interpretation of assay development, validation and performance data; analysis and interpretation of high throughput screening, potency, selectivity and mechanism of action data; programming and upkeep of assay development and screening equipment & data analysis templates. Major components of the scientist's performance rating will be based on innovation, productivity, teamwork, analytical competence and experimental decision making.
- Development of a working knowledge of a wide variety of technologies relating to reagent production, bioassays, screening and automation.
- Use of sound judgment, acquired knowledge and experience to develop new in vitro models, protocols & reagents for the identification and prioritization of active samples.
- Routine maintenance and performance testing of assay development and screening equipment.
- Develop expertise in the programming of automated equipment and data analysis templates, and the validation of automated methods. The scientist will be able to write and test complex automated procedures under minimal supervision.
- Develop expertise in biochemical, cell-based, high content and multi-parametric assays for bioactivity screening and their transfer to robotic systems for high throughput screening.
- Performance of high throughput and secondary screening of sample collections and generation of high quality screening data.
- Analysis and interpretation of assay development, high throughput screening, potency and mechanism of action data.
- Development and effective application of a broad spectrum of practical laboratory skills; including molecular biology, cell culture, biochemistry, assay development, in depth analysis of bioactivity data and the use of automated equipment.
- Conduct laboratory operations in a safe manner. Maintain familiarity with the Chemical Hygiene Plan and Radiation Safety Procedures handbook. Exhibit safety awareness and safe work practices.
- Effectively utilize standard laboratory equipment including hand pipettes, balances, pH meters, plate readers and calculators.
- Use and maintain equipment in a neat and orderly manner. Report any malfunction immediately to supervisor.
- Practice preventative maintenance on laboratory equipment and replenish laboratory supplies as stock is depleted to prevent “down-time”.
- Keep accurate, legible and complete records of all experiments and observations. Record all appropriate data electronically in AMRI databases.
- Submit acceptable written periodic reports. Prepare summaries of experimental findings reliably and independently.
- Discuss routinely with supervisor the status of assigned programs and potential problems.
- Communicate orally and in writing unexpected occurrences which could adversely affect established timetables.
- Manage workload and time to enable the incumbent to perform multiple projects effectively, and ensure all necessary paperwork is completed on a timely basis.
- Follow responsible actions regarding chemical, radiological and biological disposal. Maintain compliance with all regulations at the federal, state, and local levels.