The Senior Research Scientist I, High Content Assay Development & Screening is a specialist in the technologies required to design and produce high content screening strategies, reagents and assays for the effective selection and identification of samples meeting predefined activity criteria. They are expected to provide a source of quality ideas and to demonstrate a consistent ability to solve problems. Specific duties include: development of high content screening technology platforms, reagents and assays for testing of natural product and synthetic samples; development of technologies and platforms for the unambiguous identification of the mechanism(s) of action of actives identified by high content screens; oversight and automation of high content assays and screens; trouble shooting of automated equipment and data analysis templates; analysis and interpretation of assay development, screening & mechanism of action data; collation of data and drafting of reports for circulation to customers. Major components of the scientist's performance rating will be based on productivity, innovation, analytical competence, intellectual contributions to projects and strategic decision making. Supervision of other researchers may be required.
- Development of a working knowledge of a wide variety of technologies related to high content assay reagent production, assays, screening, automation and drug discovery.
- Development of a high level of expertise in high content assay development, automation and active selection.
- Development of a high level of expertise in the identification of the mechanism of action(s) (targets) of actives identified by high content screens.
- Establish new technology platforms for the development of custom biological reagents, next generation assays and identification of mechanisms of action and targets. Generate case studies and content for materials used to market these services.
- Establish yourself as a technical expert and resource for site management and the business development team in their efforts to market biology and in vitro pharmacology services.
- Act as a technical expert for the Lead Discovery group; volunteer suggestions on assay technologies, automation strategies and reagent procurement. Perform literature searches to collect information from a spectrum of sources. Act as a Mentor for junior scientists.
- Use of sound judgment, acquired knowledge and experience to develop new reagents, assays, protocols and strategies for the identification and prioritization of active samples. These tasks will often require extensive literature searching, as well as contact with suppliers and customers, etc.
- Recommend and implement methods to increase the quality of products and services.
- Adapt to changing priorities such that productivity and efficiency are unaffected.
- Organize work time so that several projects are run concurrently.
- Work closely with other scientists to coordinate project progress and the use of resources.
- Develop expertise in the programming, testing and validation of automated equipment and data analysis templates. The Senior Research Scientist I is expected to become able to write and test complex equipment and analysis procedures under minimal supervision.
- Development of reagents and assays for bioactivity screening and their transfer to robotic systems for high throughput and low throughput screening.
- Performance of high throughput and secondary screening of sample collections and generation of high quality screening data.
- Analysis and interpretation of assay development, high throughput screening, potency, selectivity and MOA data.
- Development and effective application of a broad spectrum of practical laboratory skills; including molecular biology, cell culture, biochemistry, assay development, in depth analysis of bioactivity data and the use of automated equipment.
- Conduct laboratory operations in a safe manner. Maintain familiarity with the Chemical Hygiene Plan and the Biosafety, Blood Borne Pathogen and Radiation Safety Procedures provided by the company. Exhibit safety awareness and safe work practices.
- Effectively utilize and teach the use of standard laboratory equipment including hand pipettes, balances, pH meters, plate readers and calculators.
- Use and maintain equipment in a neat and orderly manner. Report any malfunction immediately to supervisor.
- Practice preventative maintenance on laboratory equipment and replenish laboratory supplies as stock is depleted to prevent “down-time”.
- Keep accurate, legible and complete records of all experiments and observations. Record all appropriate data electronically in AMRI databases.
- Submit acceptable written periodic reports. Prepare summaries of experimental findings reliably and independently.
- Discuss routinely with supervisor the status of assigned programs and potential problems.
- Communicate orally and in writing unexpected occurrences which could adversely affect established timetables.
- Manage workload and time to enable the incumbent to perform multiple projects effectively, and ensure all necessary paperwork is completed on a timely basis.
- Follow responsible actions regarding chemical, radiological and biological disposal. Maintain compliance with all regulations at the federal, state, and local levels.