The Research Scientist I is expected to work under supervisory direction. Principal responsibilities may include assistance in: the development of reagents and assays for testing of natural product and synthetic samples; automation of assays and high throughput screening; potency and selectivity testing; analysis and interpretation of assay development, high throughput screening and potency data. A major component in the scientist's performance rating will be based on productivity, teamwork and cooperation.
Assist in the development of reagents through applications of molecular biology, cell biology and/or protein chromatography.
Assist in the development and validation of assays for bioactivity screening and their transfer to robotic systems for high throughput screening.
Assist in the development and testing of automated procedures.
Performance of high throughput and secondary screening of sample collections and generation of high quality screening data.
Assist in the analysis and interpretation of assay development, validation, screening and potency data. Demonstrate a clear understanding of the quality indicators required for validation of an assay, engineered cell line or protein to be used for drug discovery or evaluation.
Maintain comprehensive, up to date records of experimental methods, materials, calculations, results, observations and outcomes (decisions) in compliance with AMRI laboratory notebook policy. Record all appropriate data electronically in AMRI databases.
Develop and effectively apply a broad spectrum of practical laboratory skills; including molecular biology, cell culture, biochemistry, assay development, in depth analysis of bioactivity data and the use of automated equipment.
Conduct laboratory operations in a safe manner. Maintain familiarity with the AMRI Chemical Hygiene Plan, Biosafety and Blood Borne Pathogen procedures and Radiation Safety Procedures handbook. Exhibit safety awareness and safe work practices.
Effectively utilize standard laboratory equipment including hand pipettes, balances, pH meters, plate readers and calculators.
Use and maintain equipment in a neat and orderly manner. Report any malfunction immediately to supervisor.
Practice preventative maintenance on laboratory equipment and replenish laboratory supplies as stock is depleted to prevent “down-time”.
Submit acceptable written periodic reports. Prepare summaries of experimental findings reliably and independently.
Carry routine tasks independently through to successful completion.
Communicate orally and in writing unexpected occurrences which could adversely affect established timetables.
Follow responsible actions regarding chemical, radiological and biological disposal. Maintain compliance with all regulations at the federal, state, and local levels.
Education and/or Experience
Bachelors or Masters Degree with a major in Biology or Biochemistry, or equivalent industrial experience
Laboratory experience conducting molecular biology, cell biology, biochemistry, assay development and validation, screening or custom reagent production.
Computer training in the use of standard office software applications and databases