| Summary Description: The Staff Associate (Next Generation Sequencing Scientist and Operations Manager) will oversee the scientific activities of a high capacity, high throughput, next generation sequencing facility at the Institute for Genomic Medicine (IGM). The IGM's Genomic Analysis Facility serves as the genomic data generating hub for the IGM, drawing in samples from a wide range of internal and external collaborative projects along with clinical samples across Columbia University Medical Center and New York Presbyterian Hospital. The overarching goal of the IGM is to offer the benefits of scale, expertise, and capacity to facilitate the integration of genomic analysis across CUMC and execute a defining set of internal, world-leading, research projects that integrate directly with clinical care. As a member of this exciting effort, the Sequencing Scientist and Operations Manager will serve as the scientific expert to train and oversee the activities of a team of laboratory technicians involved in preparing sequencing libraries and generating data using the facility's 4 HiSeq 2500 sequencers. The scientist will also be responsible for developing and implementing novel techniques and assays within the group under limited supervision. The IGM is seeking out an experienced next generation sequencing and high throughput genotyping manager with expertise in Illumina sequencing workflows (including exome, RNA and genome library preparation), laboratory automation (Biomek, SciClone), and Illumina Infinium Bead Chip Genotyping (iScan, HiScan, TECAN).Responsibilities:-Manage scientific activities of the lab, including facilitating work flow, ensuring timely completion of projects, and directly supervising all laboratory staff;-Independently perform complex sequencing related experimental procedures and data analyses, and overseeing the efforts of all researchers in the laboratory;-Directly execute novel techniques and assays to meet the needs of the institute, including single-cell RNA/DNA cloning/sequencing, non-invasive prenatal testing, and low-input sequencing;-Perform follow-up validation assays including qRT-PCR, digital PCR and Taqman genotyping;-Train lab members on techniques that fall within the area of expertise;-Explore and develop new standard protocols for the sequencing lab;-Actively schedule and organize meetings pertaining to research planning and results discussion; expected to independently analyze data and present results from all research projects.|
Minimum Qualifications: Minimum required: Bachelor's degree in genetics or related biological discipline and 4 years' experience.Experience/Skills:-Experience with automation and robotics (Hamilton, Biomek, TECAN);-Strong organizational, detail-orientation, and multi-tasking skills;-Knowledge of Microsoft Office;-Prior experience managing a next generation sequencing laboratory;-Knowledge of Illumina sequencing systems, sequencing library preparation and exome capture (Agilent, Nimblegen, Roche, Kapa);-Experience with GWAS genotyping and microarray platforms such as Illumina Infinium.
Preferred Qualifications: Preferred education: Ph.D. with next generation sequencing experience, or Master's degree with 3 years' experience.
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